{"id":6266,"date":"2013-01-28T18:13:00","date_gmt":"2013-01-28T18:13:00","guid":{"rendered":"http:\/\/www.pharma-mkting.com\/lipitor-plavix-last-of-small-molecule\/"},"modified":"2019-02-21T01:17:58","modified_gmt":"2019-02-21T01:17:58","slug":"lipitor-plavix-last-of-small-molecule","status":"publish","type":"post","link":"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/blog\/lipitor-plavix-last-of-small-molecule\/","title":{"rendered":"Lipitor &#038; Plavix: The Last of the Small Molecule Best Sellers?"},"content":{"rendered":"<p>Forbes just published a list of &#8220;Best Selling Drugs of All Time&#8221; (see <a href=\"http:\/\/www.forbes.com\/sites\/simonking\/2013\/01\/28\/the-best-selling-drugs-of-all-time-humira-joins-the-elite\/\">here<\/a>). I created the following chart from the data cited (click on it for a larger view):<\/p>\n<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/1.bp.blogspot.com\/-RRw8HNQAqxg\/UQa62JbOQnI\/AAAAAAAAFWA\/Vlv1ykA6l7E\/s1600\/DrugPeakSalesChart.jpg\" imageanchor=\"1\" style=\"margin-left: 1em; margin-right: 1em;\"><img loading=\"lazy\" decoding=\"async\" border=\"0\" height=\"351\" src=\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/wp-content\/uploads\/2013\/01\/DrugPeakSalesChart.jpg\" width=\"400\" \/><\/a><\/div>\n<p>\n&#8220;Tellingly,&#8221; notes the Forbes author, Simon King, &#8220;each of the products in the list above best positioned to record an increase in peak annual sales over the next five years is a biologic; Humira, Enbrel, Rituxan, Herceptin and Lantus being the chief candidates. This is driven by a number of factors \u2013 the later launch of certain brands, for example \u2013 but also illustrates the robustness of leading biologic franchises that do not face direct substitutable generic competition.&#8221;<\/p>\n<p>But I have another take on the ascendancy of biologics in terms of dollar sales. Many of these drugs are so damn expensive that relatively few sales are required to reach the annual sales numbers heretofore reached by small molecules such as Lipitor and Plavix.<\/p>\n<p>However, even some &#8220;small molecules&#8221; may command high prices in the future. Pfizer&#8217;s Xalkori (crizotinib), for example, is a small molecule drug that was recently approved to treat a rare form of lung cancer. Pfizer plans to charge $115,200 a year per patient for treatment with&nbsp;Xalkori. At that rate, Pfizer needs only about 9,000 patients worldwide to generate $1 billion in annual sales of Xalkori. In comparison, 1,671,000 Lipitor patients are required to generate the same sales figure (see chart <a href=\"http:\/\/pinterest.com\/pin\/22025485647752126\/\">here<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Forbes just published a list of &#8220;Best Selling Drugs of All Time&#8221; (see here). I created the following chart from the data cited (click on it for a larger view): &#8220;Tellingly,&#8221; notes the Forbes author, Simon King, &#8220;each of the products in the list above best positioned to record an increase in peak annual sales [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":11033,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[12],"tags":[489,619,104,620,494,311,108,621],"topic":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lipitor &amp; Plavix: The Last of the Small Molecule Best Sellers? - Pharma Marketing Network<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/blog\/lipitor-plavix-last-of-small-molecule\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipitor &amp; Plavix: The Last of the Small Molecule Best Sellers? - Pharma Marketing Network\" \/>\n<meta property=\"og:description\" content=\"Forbes just published a list of &#8220;Best Selling Drugs of All Time&#8221; (see here). I created the following chart from the data cited (click on it for a larger view): &#8220;Tellingly,&#8221; notes the Forbes author, Simon King, &#8220;each of the products in the list above best positioned to record an increase in peak annual sales [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/blog\/lipitor-plavix-last-of-small-molecule\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharma Marketing Network\" \/>\n<meta property=\"article:published_time\" content=\"2013-01-28T18:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-21T01:17:58+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/wp-content\/uploads\/2013\/01\/DrugPeakSalesChart.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"352\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Pharma Guy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Pharma Guy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/blog\/lipitor-plavix-last-of-small-molecule\/\",\"url\":\"http:\/\/ec2-54-175-84-28.compute-1.amazonaws.com\/pharma-mkting.com\/blog\/lipitor-plavix-last-of-small-molecule\/\",\"name\":\"Lipitor & Plavix: The Last of the Small Molecule Best Sellers? 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